2011•Practical Clinical MedicineRequires access

Protective Effects of Ligustrazine on Hypoxia/Reoxygenation Injury in Cardiomyocytes

Liu Qiang

Abstract

Objective To investigate the protective effects of ligustrazine on hypoxia/reoxygenation injury and its mechanisms of action in cultured SD neonatal rat cardiomyocytes.Methods The primary cultured cardiomyocytes were randomly divided into five groups:normal group,hypoxia/reoxygenation model group,50 μg·mL-1ligustrazine group,100 μg·mL-1ligustrazine group and 150 μg·mL-1ligustrazine group,with 10 wells in each group.Superoxide dismutase(SOD) activity,malondialdehyde(MDA) concentrations and lactate dehydrogenase(LDH) content were measured.Results Ligustrazine significantly induced a increase in SOD activity and a decrease in MDA concentrations and LDH content,as compared to hypoxia/reoxygenation model group(P0.05).Conclusion Ligustrazine may protect cultured neonatal rat cardiomyocytes from hypoxia/reoxygenation injury through a mechanism involving inhibiting and scavenging free radicals.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Malondialdehyde, Medicine, Lactate dehydrogenase, Hypoxia (environmental), Superoxide dismutase, Pharmacology, Anesthesia, Internal medicine