Investigation of Mahuangtaoren Powder on serum sex hormone in mice with autoimmune thyroiditis

Objective To investigate the effect of on serum sex hormone in mice with autoimmune thyroiditis. Methods After mice models of EAT 105 were established, mice models of EAT were divided into Mahuangtaoren Powder of high-dose group, middle-dose group and low-dose group. And model group, control group and normal group were developed. After treatment destradiol and testosterone in serum of mice were measured by double antibody Radioimmunoassay. Results Destradiol in model group was higher than that in normal group (P0.01), testosterone in model group was lower than that in normal group (P0.01). Destradiol in Mahuangtaoren Powder of high-dose group, middle-dose group and low-dose group were lower than that in model group (P0.05). There were no significant differences between Mahuangtaoren Powder of high-dose group, middle-dose group and low-dose group and model group in testosterone. Conclusion Destradiol and testosterone has an effect on AIT, Mahuangtaoren Powder can decrease destradiol in serum of mice with EAT.