Clinical observation on Treatment of Intrahepatic Cholestasis of Pregnancy by Ursodeoxycholic Acid Combined with Qingyu Lidan Decoction

Objective: To explore the method,clinical efficacy and safety on treatment of intrahepatic cholestasis of pregnancy( ICP) by Ursodeoxycholic acid combined with Qingyu Lidan Decoction. Methods: 140 cases with ICP were selected,and were randomly divided into observation group and control group,70 cases per group. Patients in control group were given conventional treatment measures,and patients in observation group were given Qingyu Lidan Decoction based on control group. Two groups' pruritus score,serum total bile acid( TBA),serum total bilirubin( TBIL),indirect bilirubin( DBIL),alanine aminotransferase( ALT),aspartate aminotransferase( AST) levels,pregnancy outcome,neonatal conditions and adverse drug reactions were evaluated before treatment and two courses later after treatment. Results: Before treatment,there was no statistical difference on pregnant women's pruritus score,TBA,TBIL,DBIL,ALT and AST( t = 0. 12 ~ 1. 63,P 0. 05). After treatment,control group's pruritus score was decreased( t = 4. 10,P 0. 05),and serum TBA decreased( t = 6. 12,P 0. 01),and observation group's pruritus score,serum TBA,TBIL,DBIL,ALT,AST levels were all decreased( t = 3. 97 ~ 6. 73,P 0. 05 or P 0. 01). Observation group's pruritus score,serum TBA, TBIL,DBIL,ALT,AST levels were all lower than those of control group( t = 3. 26 ~ 4. 67,P 0. 05). The total effective rates in observation group and control group were 88. 57% and 75. 71%( χ2= 4. 20,P 0. 05). Observation group' s gestational weeks were longer than that of control group( t = 3. 71,P 0. 05),and vaginal delivery rates were higher, yet cesarean section rate was lower than that of control group( χ2= 4. 52,P 0. 05). Newborns' fetal distress,premature birth,neonatal asphyxia and postpartum hemorrhage rates in observation group were all lower than those of control group( χ2= 3. 69 ~ 7. 20,P 0. 05 or P 0. 01),and Apgar score was higher than that of control group( t = 3. 87,P 0. 05). Except for mild skin symptoms appearing in one patient of observation group,there were no other adverse reactions in two groups. Conclusion: It has good curative effect on treatment of ICP by Ursodeoxycholic acid combined with Qingyu Lidan Decoction,and it effectively eliminates patients' symptoms of itching and jaundice,improves liver function,restores normal level of bile acid and hepatic enzymes,and ensures perinatal maternal and children's safety,so the curative effect is obviously better than that of pure western medicine treatment,and it has certain guiding significance to ICP's clinical treatment.