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1996•Chinese Journal of PharmaceuticalsRequires access

HPLC DETERMINATION OF CHLORPROMAZINE HYDROCHLORIDE INJECTION

Chen Zhen

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Abstract

An improved HPLC method is described for the quantitative determination of chlorpromazine hydrochloride injection. Using phenyl silica column and UV detector, with methanol-acetonitrile-0.02 mol/L potassium dihydrogen phosphate solution(100:150:350) as the mobile phase, an almost linear calibration curve was obtained(r=0.9999). The average recovery and RSD were 100. 13%, and 0.85%, respectively.

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What this paper is about

An improved HPLC method is described for the quantitative determination of chlorpromazine hydrochloride injection. Using phenyl silica column and UV detector, with methanol-acetonitrile-0.02 mol/L potassium dihydrogen phosphate solution(100:150:350) as the mobile phase, an almost linear calibration curve was obtained(r=0.9999). The average recovery and RSD were 100. 13%, and 0.85%, respectively.

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Available abstract

An improved HPLC method is described for the quantitative determination of chlorpromazine hydrochloride injection. Using phenyl silica column and UV detector, with methanol-acetonitrile-0.02 mol/L potassium dihydrogen phosphate solution(100:150:350) as the mobile phase, an almost linear calibration curve was obtained(r=0.9999). The average recovery and RSD were 100. 13%, and 0.85%, respectively.

Key concepts: Chemistry, Chromatography, High-performance liquid chromatography, Calibration curve, Acetonitrile, Potassium, Methanol, Quantitative analysis (chemistry)

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