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2010•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

Effect of Huanglian Jiedu Decoction on the Expression of MCP-1/CCR2 mRNA in Atherosclerosis Rats

Guoqiang Li

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Abstract

Objective To study the effect of Huanglian Jiedu Decoction on the expression of MCP-1/CCR2 mRNA in rats with atherosclerosis(AS).Methods After the AS model was established,AS rats were divided into model group,low-,middle-and high-dosage Huanglian Jiedu Decoction groups and atorvastati group.Meanwhile,a normal control group was also set up.The expression of MCP-1/CCR2 mRNA in aorta was tested by RT-PCR method.Results Compared with the model group,the expression of aortic MCP-1/CCR2 mRNA was significantly 1ower in middle-and high-dosage Huanglian Jiedu Decoction groups and in atorvastati group(P 0.05 or P 0.01).Conclusion Huanglian Jiedu Decoction can decrease the expression of MCP-1/CCR2 mRNA in aorta,reduce local inflammatory reaction,and relieve the aortic damage.

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What this paper is about

Objective To study the effect of Huanglian Jiedu Decoction on the expression of MCP-1/CCR2 mRNA in rats with atherosclerosis(AS).Methods After the AS model was established,AS rats were divided into model group,low-,middle-and high-dosage Huanglian Jiedu Decoction groups and atorvastati group.Meanwhile,a normal control group was also set up.The expression of MCP-1/CCR2 mRNA in aorta was tested by RT-PCR method.Results Compared with the model group,the expression of aortic MCP-1/CCR2 mRNA was significantly 1ower in middle-and high-dosage Huanglian Jiedu Decoction groups and in atorvastati group(P 0.05 or P 0.01).Conclusion Huanglian Jiedu Decoction can decrease the expression of MCP-1/CCR2 mRNA in aorta,reduce local inflammatory reaction,and relieve the aortic damage.

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Available abstract

Objective To study the effect of Huanglian Jiedu Decoction on the expression of MCP-1/CCR2 mRNA in rats with atherosclerosis(AS).Methods After the AS model was established,AS rats were divided into model group,low-,middle-and high-dosage Huanglian Jiedu Decoction groups and atorvastati group.Meanwhile,a normal control group was also set up.The expression of MCP-1/CCR2 mRNA in aorta was tested by RT-PCR method.Results Compared with the model group,the expression of aortic MCP-1/CCR2 mRNA was significantly 1ower in middle-and high-dosage Huanglian Jiedu Decoction groups and in atorvastati group(P 0.05 or P 0.01).Conclusion Huanglian Jiedu Decoction can decrease the expression of MCP-1/CCR2 mRNA in aorta,reduce local inflammatory reaction,and relieve the aortic damage.

Key concepts: Decoction, Medicine, CCR2, Messenger RNA, Pharmacology, Normal group, Inflammation, Internal medicine

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Effect of Huanglian Jiedu Decoction on the Expression of MCP-1/CCR2 mRNA in Atherosclerosis Rats — Research Paper | ScholarLens