Antibacterial Activity of Cefdinir and Other Four Antimicrobials Against Streptococcus pneumoniae

OBJECTIVE To evaluate the antibacterial activity of cefdinir and other four antimicrobials against 95 strains of Streptococcus pneumoniae in vitro. METHODS Minimal inhibitory concentrations (MIC) were ~determined by dilution method according to NCCLs. RESULTS Penicillin sensitive S. pneumoniae showed the highest susceptibility to cefdinir with susceptible rate of 98.44%, but were resistant to ciprofloxacin. ~S. pneumoniae except penicillin sensitive strains showed highest susceptibility to gatifloxacin with over 90% ~susceptiblility, and also showed good susceptibility to cefdinir and levofloxacin, but were risistant to cefaclor and ciprofloxaoin with susceptible rate of 61.55% and 46.38%. CONCLUSIONS Cefdinir has an powerful antibacterial activity against S. pneumoniae and it is valuable to treat S. pneumoniae infection. The new fluoroquinolones have better antibacterial activity to S. pneumoniae including PISP and PRSP and they can be of the first choice to treat S. pneumoniae infection.