Denaturing high performance liquid chromatography and its progress in mutate detection
Hua He
Abstract
Hua He
Abstract
Denaturing high performance liquid chromatography(DHPLC)with its efficiency,accuracy and automati- zation has found increasing advantages in screening out working with single nucleotide polymorphism(SNP).This review discussed the mechanism of DHPLC and compared it with many other methods for detecting SNP in detail which implies that the prospect of DHPLC in this field is anticipated.
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Denaturing high performance liquid chromatography(DHPLC)with its efficiency,accuracy and automati- zation has found increasing advantages in screening out working with single nucleotide polymorphism(SNP).This review discussed the mechanism of DHPLC and compared it with many other methods for detecting SNP in detail which implies that the prospect of DHPLC in this field is anticipated.
Key concepts: Denaturing high performance liquid chromatography, Chemistry, Chromatography, Single-nucleotide polymorphism, SNP, High-performance liquid chromatography, Biochemistry, Gene