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2010•Zhonghua zhongyiyao xuekanRequires access

Induction of Human Gastric Cancer Cell BGC-823 Apoptosis by Curcumin with Illumination

Liu Yan

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Abstract

Objective:To investigate the effects of curcumin with illumination on induction of apoptosis in human gastric cancer cell BGC-823. Methods:BGC-823 cell was treated by curcumin with illumination. MTT was used to measure inhibitory effects of curcumin on proliferation of BGC-823 cells. Hoechst33258 staining and TEM were conducted to determine the cell morphology. Flow cytometry was used to investigate the apoptosis and cell cycle distribution of BGC-823 cells. Results:Cell proliferation was markedly inhibited by curcumin with illumination. The typical apoptotic morphology can be seen caused by curcumin of 5μmol/L with illumination. By analysis with flow cytometry,cell cycles showed G0/G1 arrest after treatment with curcumin with illumination.Conclusion:Curcumin with illumination has the effect of inducing cell apoptosis in BGC-823 cells,suggests a potential application of photodynamic therapy for tumor.

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What this paper is about

Objective:To investigate the effects of curcumin with illumination on induction of apoptosis in human gastric cancer cell BGC-823. Methods:BGC-823 cell was treated by curcumin with illumination. MTT was used to measure inhibitory effects of curcumin on proliferation of BGC-823 cells. Hoechst33258 staining and TEM were conducted to determine the cell morphology. Flow cytometry was used to investigate the apoptosis and cell cycle distribution of BGC-823 cells. Results:Cell proliferation was markedly inhibited by curcumin with illumination. The typical apoptotic morphology can be seen caused by curcumin of 5μmol/L with illumination. By analysis with flow cytometry,cell cycles showed G0/G1 arrest after treatment with curcumin with illumination.Conclusion:Curcumin with illumination has the effect of inducing cell apoptosis in BGC-823 cells,suggests a potential application of photodynamic therapy for tumor.

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Available abstract

Objective:To investigate the effects of curcumin with illumination on induction of apoptosis in human gastric cancer cell BGC-823. Methods:BGC-823 cell was treated by curcumin with illumination. MTT was used to measure inhibitory effects of curcumin on proliferation of BGC-823 cells. Hoechst33258 staining and TEM were conducted to determine the cell morphology. Flow cytometry was used to investigate the apoptosis and cell cycle distribution of BGC-823 cells. Results:Cell proliferation was markedly inhibited by curcumin with illumination. The typical apoptotic morphology can be seen caused by curcumin of 5μmol/L with illumination. By analysis with flow cytometry,cell cycles showed G0/G1 arrest after treatment with curcumin with illumination.Conclusion:Curcumin with illumination has the effect of inducing cell apoptosis in BGC-823 cells,suggests a potential application of photodynamic therapy for tumor.

Key concepts: Curcumin, Flow cytometry, Apoptosis, Cell, Cell cycle, Cell growth, Chemistry, Cancer cell

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