The Expressions and Significance of E-cadherin and Beta-catenin in Epithelial Ovarian Tumor and the Metastatic Lesions of Ovarian Carcinoma

Objective Discuss the relationship between the expressions of E-cadherin,beta-catenin and the clinic pathology of epithelial ovarian cancer as well as the transferment.Methods The expression of E-cadherin and beta-catenin was detected with immunohistochemistry staining in ovarian cancer and metastatic lesions,borderline ovarian tumors,benign ovarian tumors and normal ovarian tissues.Results The expression of E-cadherin was negative in normal ovarian tissues.The expression of E-cadherin in ovarian cancers was obvious lower than that in benign and borderline ovarian tumors(P 0.05).The expression of E-cadherin was significantly decreased in the poorly differentiated tumor and in the advanced ovarian cancers(P0.05),and also in the residual sizes2cm(P0.05).On the contrary,the expression of beta-catenin in ovarian cancers was obviously high compared with its expression in different ovarian tissues(P0.05).Its expression in borderline ovarian tumors was higher than that in normal ovaries and benign ovarian tumors(P0.05).Compared with the expression in mucous cystic adenocarcinoma and endometrioid carcinoma,beta-catenin had the highest positive expression in serous cystic adenocarcinoma(P 0.05).It was up regulated along with the progressing of differentiation stages(P 0.05).The immunoreactivity for E-cadherin and beta-catenin was significantly increased in the metastatic lesions of ovarian carcinoma compared with the respective primary lesions(P0.05).Conclusion E-cadherin and beta-catenin played very important roles in the happening and development of epithelial ovarian cancers.The united examination can evaluate the prognosis of epithelial ovarian cancers well.E-cadherin and beta-catenin may be changed with the transferring of epithelial ovarian cancers.The result can provid the theoretical evidence for the better treatment.