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2003•Journal of Apoplexy and Nervous DiseasesRequires access

Expression of IGF-I mRNA in focol cerebral ischemia injury in rats

Shen Shu-n

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Abstract

Objective The purpose of this study was to observe the expression characteristics of IGF I mRNA in rat's focal cerebral ischemia injury and discuss it's modulation mechanism.Methods Rat's focal ischemia models were performed by injecting blood coagulation into internal carotid artery.The expression of IGF I mRNA was tested in cerebral ischemia center areas and perifocal areas with the methods of in situ hybridization and RT PCR.Results The expression of IGF I mRNA increased both in cerebral ischemia center areas and perifocal areas in rat's focal cerebral ischemia injury,especially in ischemia perifocal areas.Conclusions IGF I plays a protective role in focal cerebral ischemia.

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What this paper is about

Objective The purpose of this study was to observe the expression characteristics of IGF I mRNA in rat's focal cerebral ischemia injury and discuss it's modulation mechanism.Methods Rat's focal ischemia models were performed by injecting blood coagulation into internal carotid artery.The expression of IGF I mRNA was tested in cerebral ischemia center areas and perifocal areas with the methods of in situ hybridization and RT PCR.Results The expression of IGF I mRNA increased both in cerebral ischemia center areas and perifocal areas in rat's focal cerebral ischemia injury,especially in ischemia perifocal areas.Conclusions IGF I plays a protective role in focal cerebral ischemia.

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Available abstract

Objective The purpose of this study was to observe the expression characteristics of IGF I mRNA in rat's focal cerebral ischemia injury and discuss it's modulation mechanism.Methods Rat's focal ischemia models were performed by injecting blood coagulation into internal carotid artery.The expression of IGF I mRNA was tested in cerebral ischemia center areas and perifocal areas with the methods of in situ hybridization and RT PCR.Results The expression of IGF I mRNA increased both in cerebral ischemia center areas and perifocal areas in rat's focal cerebral ischemia injury,especially in ischemia perifocal areas.Conclusions IGF I plays a protective role in focal cerebral ischemia.

Key concepts: Ischemia, Messenger RNA, In situ hybridization, Medicine, microRNA, Middle cerebral artery, Pathology, Internal medicine

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