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Research Advance of Biomarkers in the Early Diagnosis of Sepsis

Bin Chen

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Abstract

It is important to diagnose sepsis in the early stage,while there are similar clinical manifestations of sepsis and non-infectious systemic inflammatory response syndrome.There are some biomarkers in the diagnosis of sepsis.The C-reaction protein is a non-specific inflammation indicator and IL-6 is an important cytokine which increases during sepsis,but with low specificity.The value of procalcitonin is still controversial.NT-proBNP can be used as a marker in heart dysfunction during sepsis.MD-proADM,proET-1 and soluble triggering receptor expressed on myeloid cells-1(TREM-1)are new biomarkers in sepsis,especially sTREM-1,which may be the most hopeful biomarker in the diagnosis of sepsis.

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What this paper is about

It is important to diagnose sepsis in the early stage,while there are similar clinical manifestations of sepsis and non-infectious systemic inflammatory response syndrome.There are some biomarkers in the diagnosis of sepsis.The C-reaction protein is a non-specific inflammation indicator and IL-6 is an important cytokine which increases during sepsis,but with low specificity.The value of procalcitonin is still controversial.NT-proBNP can be used as a marker in heart dysfunction during sepsis.MD-proADM,proET-1 and soluble triggering receptor expressed on myeloid cells-1(TREM-1)are new biomarkers in sepsis,especially sTREM-1,which may be the most hopeful biomarker in the diagnosis of sepsis.

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Available abstract

It is important to diagnose sepsis in the early stage,while there are similar clinical manifestations of sepsis and non-infectious systemic inflammatory response syndrome.There are some biomarkers in the diagnosis of sepsis.The C-reaction protein is a non-specific inflammation indicator and IL-6 is an important cytokine which increases during sepsis,but with low specificity.The value of procalcitonin is still controversial.NT-proBNP can be used as a marker in heart dysfunction during sepsis.MD-proADM,proET-1 and soluble triggering receptor expressed on myeloid cells-1(TREM-1)are new biomarkers in sepsis,especially sTREM-1,which may be the most hopeful biomarker in the diagnosis of sepsis.

Key concepts: Procalcitonin, Sepsis, Biomarker, Medicine, Systemic inflammatory response syndrome, Inflammation, Immunology, Myeloid

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