Biomarkers of sepsis

Sepsis,the leading cause of death in critically ill patients,is a systemic inflammatory response syndrome caused by pathogens,which could further develop into severe sepsis or septic shock. Early recognition,timely diagnosis,effective prevention and treatment are critical to improve the outcome of sepsis. Biomarkers play a significant role in the prognosis and diagnosis of sepsis. While none of these biomarkers have sufficient specificity or sensitivity to be employed in clinical practice. Biomarkers based on the abnormal inflammatory response and immunosuppression,combining with epigenetic markers,single nucleotide polymorphism and gene duplication of PIRO Stratification System will provide scientific basis for early alert,diagnosis and treatment of sepsis.