A clinical study of mifepristone combined with different administration of misoprostol for medical abortion in the earliest day of pregnency

Objective To evaluate the effect of mifepristone combined with different administration of misoprostol for medical abortion in the earliest day of pregnency. Methods A total of 70 healthy women for medical abortion with gestation of up to 37 days were recruited into this study,which were randomly divided into two groups, group I and group Ⅱ. To terminate pregnancy,they took 150 mg mifepristone orally on the first day, followed with 400μg misoprostol in 36~48 hours by vagina in group I and sublingual administration in group Ⅱ.Results The complete abortion rate was 92.86% in total,while is was 97.06% and 88.89% respectively in vaginal group and sublingual group.There was significant difference of the complete abortion rate between two groups( P0.05).Incomplete abortion was not faund in two groups. The total failure rate was 7.14% , while it was 2.94% (1 /34) in vaginal group and 11.11%(4/36)in oral sublingual group;there was significant difference of failure rate between two groups(P0.05). The level of blood β-hCG was correlated with the time of vaginal bleeding(P=0.000). Conclusions Mifepristone combined with vaginal misoprostol results in higher complete abortion rate and lower failure rate as compared with mifepristone plus sublingual misoprostol,but it should be careful about the ectopic pregnancy.