Pharmacodynamics of Sparfloxacin Dispersible Tablet in Patients with MDR-TB

Objective: To study the appropriate dose of sparfloxacin dispersible tablet(SPLX) given orally and through interven tional approach.Method: The concentration of sparfloxacin in serum were measured by HPLC MIC MBC time-bactei degradient and time-drug resistance gradient were detecd in vitro.Result: The peak concentration of sparfloxacin in serum of 8 patients are 4.52±0.72 mg/L in 1.22 hours and the mininal concentration of sparfloxacin in serum was 0.52±0.26 mg/L after patients were given a single dose with in 24 hours.The apparent volume of distribution was 77.48±8.33 L.The value of MIC and MBC were 0.5/mg.L and 1mg /L.The range of drug resistance gradient was 0.5 mg/L to 48/ mg/L.Conclusion: The dosage and internal time of sparfloxacin in patients with pulmonary tuberculosis would be controlled the concentration of sparfloxacin in interventional therapy should be above 48mg/L.