2013•Wuhan Daxue xuebao. Yixue banRequires access
Detection of Osteopontin as a Potential Biomarker for Metastasis and Recurrence in Gastric Cancer
Xinguang Qiu
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Abstract
Objective: To evaluate the value of osteopontin(OPN) detection in forecasting the postoperative recurrence and survival rate of gastric cancer.Methods: Serum OPN level of 135 patients with gastric cancer was detected before operation by enzyme-linked immunosorbent assay(ELISA),and serum samples of 28 healthy volunteers were also analyzed as control group.The correlation of serum OPN level to metastasis and recurrence of gastric cancer was analyzed.Results: Serum OPN level was significantly higher in gastric cancer group than in control group as(111.70±9.26) μg/L vs(36.27±4.90) μg/L(P0.01).Logistic regression showed that serum OPN level was significantly associated with tumor size(P0.01).Serum OPN level was demonstrated significant associated with gastric cancer patient's recurrence and survival(P0.01).COX multivariate analysis showed that serum OPN level was an independent predictor for gastric cancer recurrence and survival.Conclusion: Serum OPN level may be a potential biomarker for predicting postoperative recurrence and survival of gastric cancer patients.