Changes of plasma visfatin level in rats with type 2 diabetes after different interventions

Objective To investigate the change of plasma visfatin level and the relationship between plasma visfatin level with fasting plasma glucose(FPG),fasting insulin(FINS),homeostasis model assessment(HOMA),total cholesterol(TC),triglyceride(TG),high density lipoprotein (HDL),low density lipoprotein(LDL),free fatty acids(FFA)and body weight to give different interventions in rats with type 2 diabetes.Methods With high-sucrose and high-fat diet+STZ(30 mg/kg)inducing Wistar rats,rats model with type 2 diabetes melitus was developed by means of FPG11.1 mmol/L(DM,n=28),and then given repaglinide+dimethylbiguanide(B,n=7), rosiglitazone+dimethylbiguanide(C,n=7),insulin+dimethylbiguanide(D,n=7),PS(E,n=7) in DM.Plasma visfatin levels were measured by ELISA in rats with type 2 diabetes and control after 8 weeks.The relationship of plasma visfatin level with FPG,FINS,HOMA,TC,TG,HDL, LDL,FFA and body weight were analyzed.Results FPG,FINS,HOMA,TC,TG,HDL,LDL, FFA,visfatin and body weight in diabetes rats and obese rats significantly increased and HDL significantly reduced compared with NC.FPG,FINS,HOMA in B-E groups significantly reduced compared with F.FFA in C group significantly reduced and visfatin level significantly increased compared with other groups.Correlation and multiple regression analysis showed that plasma visfatin level was closely correlated with glucolipid metabolism and body weight.Conclusion It is possible that peroxisome proliferator-activated receptors nuclear receptor joins in the express and secretory activity of visfatin.Visfatin,which is closely correlated with glucolipid metabolism and body weight,may be one of the targets of peroxisome proliferator-activated receptors excitomoter drug treat DM.