Benazepril vs enalapril treatment of mild to moderate essential hypertension of old patients in district

Objective To compare the efficacy and safety of benazepril and enalapril in treatment of mild to moderate essential hypertension of old patients in district.Methods Patients with mild to moderate essential hypertension of old patients(n=116) were randomly divided into two groups.Benazepril group(n=58,M 31,F 27,age 66.9±1.8a) was treated with benazepril 10mg,po,qd for 4wk and enalapril group(n=58,M 34,F 24,age 65.2±1.5a) was treated with enalapril 10mg,po,qd for 4wk,then,fllowed by dose doubling for another 4wk in those patients with seated diastolic blood pressure ≥12kPa or systolic blood pressure ≥18.8kPa.At the same time,each group 20 patients were evaluated by ambulatory 24h blood pressure monitoring before and after 8wk treatment.Results The blood pressure significantly decreased after treatment with benazepril and enalapril and the effective rates were 94.82% and 84.48%(P0.05) respectively at the end of 8wk.The trough to peak ratio for SBP DBP were calculated as 60.5%/57.7% for benazepril and 55.2%/52.9% for enalapril.Adverse reaction of benazepril group were the same as those enalapril group(10.34% vs 18.97%,P0.05).Conclusion Benazepril is an effective and safe drug in treatment of mild to moderate essential hypertension of old patients in district.