Antioxidative Effects of Panax Notoginseng Saponins on Rats with Acute Lung Injury Induced by Oleic Acid

Objective To explore the antioxidative effects of panax notoginseng saponins(PNS) on rats with acute lung injury induced by oleic acid.Methods 40 healthy male SD rats were randomly divided into three groups:(1) normal control group(n=8);(2) acute lung injury group(n=8),rats were injected oleic acid(0.12 mL/kg);(3) PNS intervention group(n=24),rats were injected by PNS(25 mg/kg,50 mg/kg,75 mg/kg,respectively) after oleic acid(0.12 mL/kg) injection 15 minutes.Animals of all three groups were sacrificed after 4 hours.The pathological changes,lung wet/dry(W/D) weight ratio,contents of malondialdehyde(MDA) and nitric oxide(NO),and activities of myeloperoxidase(MPO),nitric oxide synthase(NOS),and superoxide dismutase(SOD) were measured in lung tissue.Results(1) Pathological changes of acute lung injury were reduced significantly in PNS intervention groups.(2) Compared with normal control group,W/D,MPO,NO,NOS and MDA in acute lung injury group were all higher(P0.05),SOD was lower;W/D,MPO,NO,NOS and MDA in PNS groups were all lower than acute lung injury group(P0.05),SOD was higher.Conclusion These results suggest that PNS can alleviate lung inflammation,decrease the W/D,MPO,MDA,NO,NOS and increase SOD,and decrease the degree of acute lung injury in rats injecteel by oleic aeid,and that may be involved in increase of lung antioxident action.