Comparative study of Baishao aqueous extract and paeoniflorin on mouse with leukopenia induced by cyclophosphamide

Objective To comparatively observe the effects of Baishao aqueous extract and paeoniflorin on mouse model with leukopenia induced by cyclophosphamide(CTX).Method Baishao aqueous extract and paeoniflorin was continuously given to mice orally for 10 days while CTX was administered intraperitoneally in the sixth and seventh day to induce mouse leukopenia disorder.The changes of blood white cell count and the amount of karyote in bone marrow,as well as the coefficient of liver,spleen,or thymus gland were observed between the drug-pretreated mice and control mice.Result Mice obviously presented leukopenia disorder after received cyclophosphamide for 2 days(100 mg·kg-1·d-1,intraperitoneally),including the significant decrease of the amount of blood white cell or the amount of karyote in bone marrow,as well as the lowered coefficient of liver,spleen or thymus gland,respectively,compared with the control mice.Pretreatment with Baishao aqueous extract and paeoniflorin increased significantly the decreases in bone marrow,as well as the lowered coefficient of spleen in mice with leukopenia disorder.Conclusion Baishao aqueous extract and paeoniflorin improve effectively the mice with leukopenia disorder induced by CTX.