2008•Journal of Shantou University Medical CollegeRequires access
Effect of Electroacupuncture on the Expression of Nogo-A Protein in Rats with Spinal Cord Injury
Jia-Bei Liu
Open publisher page 1 citations
Abstract
Objective:To study the effect of electroacupuncture on the expression of Nogo-A protein in rats with spinal cord injury(SCI).Methods: Ninety-six adult Wistar rats were randomly assigned into control group(A),SCI group(B),sham-treatment group(C)and electroacupuncture treatment group(D).Group B,C and D were received transect SCI at the T9 vertebrae level while group A was just opened the vertebra and their spinal cords were not wounded.Group D was treated with electroacupuncture.All the spinal cords of the trauma section were taken out at different time points after o-peration.Western blot and immunohistochemical methods were used to examine the change of the expression of Nogo-A in these tissue.Results: Just minim Nogo-A was found in the control group,while the manifold expression of Nogo-A was found after operation,especially at the end of the second week,the expression was inhibited by electroacupuncture.Conclusion: Nogo-A is a major suppressor factor of spinal cord nerve fiber regeneration after SCI,and the electroacupuncture can obviously inhibit the expression of Nogo-A protein.