Experimental Study on the Evaluation of Chronic Renal Failure by Ultrasonic Integrated Backscatter xamination in Rabbits

Objective To explore the availability of ultrasound integrated backscatter(IBS) technique evaluation rabbit chronic renal failure(CRF) renal damage application value.Methods Fifteen healthy male rabbits were established the model of CRF and then different examinations were carried out at the last day of every two weeks(W2,W4,W6,and W8),with the data examined before the day of first injection as control(W0).Draw the values of IBS,the IBS%,serum creatinine(Scr) and blood urea nitrogen(BUN) and its kidney was removed for pathological examination by two-dimensional ultrasound techniques.Results ①After W2,the IBS% of the renal cortex began to increase significantly.After W2,the IBS% of renal cortex at each time point was statistically different,as compared with that at W0(P0.05).After W4,the IBS% of renal medulla began to increase significantly.After W4,the IBS% of renal medulla at each time point was statistically different,as compared with that at W0(P0.05).The changes of the IBS% of the renal cortex occurred earlier than those of renal medulla.②Two-dimensional ultrasonic examinations showed that the vertical diameter and anteroposterior diameter increased significantly.After W2 the values of both diameters at each time point were statistically different,as compared with those at W0(P0.05).③After W6,the level of serum creatinine and blood urea nitrogen began to increase significantly.The values examined were statistically different as compared with those at W0(P0.05).④Pathological changes were mainly found in the renal cortex at the early stage.These changes began at W2 and turned into worse significantly at W8.Conclusions During the development of chronic renal failure in rabbits,ultrasound integrated backscatter technology could reflect the pathological injuries of the kidney and provide more information for clinical monitoring and evaluating renal injuries during the development of CRF.