Effects of different substitution hydroxyethyl starch in volume replacement therapy on haemodynamic variables and blood coagulation functions

Objective To investigate the effects of different substitution hydroxyethyl starch(HES) for general surgery patients in volume replacement therapy on haemodynamic variables and blood coagulation functions during operation. Methods Sixty-seven patients ASAⅠ-Ⅱ undergoing selective and non-cardiac surgery were assigned randomly to 3 groups:R1 group(6% HES130/0.4group, n=23), R1 group(6% HES200/0.5 group, n=24) and group C (Ringer locke liquor group, n=20), hemodynamic and blood coagulation data, the hemoglobin(Hb), blood platelet count(Plt),prothrombin time(PT), activated partial thromboplastin time(APTT) were measured on the day before operation and on the postoperative day 1. Results Hemodynamic variables had no significant difference with the baseline and during each stage time of surgery in each groups, HB, Plt, PT, APTT had no significant difference after the volume replacement therapy in each groups, P0.05. Compared with group C,patients in R1 and R2 groups maintained stable haemodynamics with significant lower dose of infusion volume,P0.05. Conclusion 6%HES 130/0.4 and 6% HES200/0.5 in appropriate dose are safe and effective in volume replacement therapy,and they have little influence on blood coagulation functions.