Comparison of effects of pidotimod and spleen aminopeptide on clinical symptoms and Th1/Th2 cytokine in children with RRI

Purpose To compare the effect of pidotimod and spleen aminopeptide on clinical symptoms and Th1/Th2 cytokine in children with recurrent respiratory tract infection(RRI).Methods 86 children with RRI were randomly divided into treatment group and control group.They received pidotimod and spleen aminopeptide respectively for 3 months besides routine treatment.The levels of interleukin-4(IL-4) and interferon-γ(IFN-γ) in cultured supernatant peripheral blood mononuclear cells were compared before and after treatment.Times of MPP,duration of clinical symptoms(fever,cough,antiadoncus and Lung NaLuo sound) during treatment,and clinical efficacy after treatment were compared.Results Compared with control group,the times of MPP during treatment was significantly decreased(P0.01),and the duration of clinical symptoms during treatment was significantly shortened(P0.01),and the clinical efficacy in treatment was significantly better than that in control group(P0.05).Furthermore,the levels of IL-4 and IFN-γ of both group were significantly different statistically(P0.01).Conclusion Pidotimod has better curative effect to children with RRI than spleen aminopeptide,probably related to modulating the balance of Th1/Th2 cytokine.