Effects of Atorvastatin on hs-CRP,IL-6,TNF-α and endothelium-dependent vasodilation in elderly patients with hypertension

Objective To investigate the influence of different doses atorvastatin on the serum lipid and High Sensitive C-Reactive Protein(hs-CRP),IL-6,TNF-α and endothelium-dependent vasodilation in elderly patients with hypertension.Methods 84 elderly patients with hypertension were divided into three groups randomly:the control group,the atorvastatin treatment group A(10 mg/d) and the atorvastatin treatment group B(20 mg/d).Each group received regular anti-hypertension treatment,the atorvastatin treatment groups were administered orally atrovastatin.Therapeutic time was 8 weeks.Blood pressure,serum total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),hs-CRP,IL-6,TNF-α contents and endothelium-dependent vasodilation were measured before and after therapy.Results Compared with before therapy,blood pressure after therapy in the three groups were significantly decreased(P0.05 or P0.01).The TC,LDL-C,hs-CRP,IL-6,TNF-α after therapy in the three groups were decreased,and the atorvastatin treatment groups were significantly decreased(P0.05 or P0.01).The endothelium-dependent vasodilation was significantly improved in the three groups(P0.05 or P0.01).Compared with the control group,the TC,LDL-C and hs-CRP in groups A and B,the IL-6,TNF-α in the group B were significantly decreased(P0.05 or P0.01);Compared with the group A,hs-CRP,LDC-C in group B was significantly decreased(P0.01).The endothelium-dependent vasodilation in group B improved more significantly than group A.Conclusion Atorvastatin can effectively decrease the serum lipid,alleviate vascular in flammation response and improve endothelium-dependent vasodilation in elderly patients with hypertension,and the doses of 20 mg/d is better than 10 mg/d.