Effects of edaravone pretreatment on acute lung injury in rat model of injected oleic acid

Objective To investigate the effect of edaravone pretreatment on acute lung injury in rat model of injected oleic acid.Methods Thirty SD rats were randomly divided into 3 groups (n=10):group A (sham operated group),group B (ALI group),group C (edaravone group).Group A received intraperitoneal injection of normal saline 10 mL/kg,than prepared model by intravenous injection normal saline 0.1 mL/kg.Group B received intraperitoneal injection of normal saline 10 mL/kg,than prepared model by intravenous injection OA 0.1 mL/kg.Group C received intraperitoneal injection of edaravone 10 mL/kg,than prepared model by intravenous injection OA 0.1 mL/kg.PO2 of blood in the aorta abdominalis were measured.The expression of TNF-α,NO,MDA,SOD was examined by ELISA.Wet/dry weight of lung tissue was calculated.Results The levels of PO2 and SOD in group A were more than that in group B and C.The increase in the levels of PO2 and SOD in groups C was more than that in group B (P 0.05).The levels of W/D,TNF-α,NO,MDA in group A were less than that in group B and C.There were significant differences in the levels of W/D,TNF-α,NO,MDA between groups B and A (P 0.05).And compared with group B,the increase in the levels of W/D,TNF-α,NO,MDA in groups C was less than that in group B (P 0.05).Conclusion Pretreatment with edaravone can attenuate ALI by scavenging free radical and inhibiting proinflammatory cytokines.