Investigation of reference interval of mean platelet volume by hematology analyzer Sysmex XE-2100

Objective To investigate the reference interval of mean platelet volume( MPV) in healthy adults' venous blood by hematology analyzer Sysmex XE-2100,and establish the suitable reference interval to our laboratory. Methods Reference individual selection,specimen collection and transportation,specimen detection and data analysis were accomplished according to the Clinical and Laboratory Standards Institute ( CLSI) C-28A2,and the new reference interval was validated and compared. Results The results of MPV in healthy subjects did not conform to normal distribution,and the results between male and female showed no statistical significance ( P 0. 05). The combined reference interval of MPV was 8. 4-12. 9 fL. The new reference interval was validated by the results of MPV determination in 200 healthy subjects. There were 3% data out of the reference interval. Conclusions The reference interval of different gender can be combined,and the new reference interval can be acceptable.