The value of CD_(116) expression in acute leukemia

Objective:To explore the clinical significance of GM-CSF receptor (CD 116 ) expression in acute leukemia.Methods:Immnophenotypic and cytogenetic features of blast cells in 114 acute leukemia were analysed.Results:Blast cells from ALL patients were CD 116 negative,and CD 116 was expressed in blasts from 42.4 % of AML, incidence of CD 116 expression in each FAB subtype was also different,CD 116 expression were significantly more frequent in AML-M 4、M 5,the highest expression was seen in M 5 ( 83.3 %).In CD 116 +AML,no correlation was found between CD 116 and cytogenetic abnormalities.Conclutions:CD 116 may be considered a sensitive and specific marker to detect leukemia cells committed to the myeloid lineage, especially the monasocytic commitment, CD 116 combining CD 4 may be important to diagnose M 5.