The protective effect of atorvastatin on renal interstitial fibrosis of unilateral obstruction in rats

Objective To investigate the protective effect of atorvastatin on renal interstitial fibrosis of unilateral obstruction(UUO) in rats.Methods The rats models of renal interstitial fibrosis were made by unilateral urethral ligation,the rats were randomly divided into three groups,sham operation group,model group and treatment group.The total cholesterol was detected,the histological changes in obstructed kidney were observed by HE stain and Masson stain.The changes of expression of HGF were analyzed by routine immunohistochemical method.Results As compared with those in sham operation group,there were no significant differences in the levels of TC between model group and treatment group(P 0.05).The renal interstitial injury in model group was significantly severer than that of sham operation group(P 0.05),however,which in treatment group was obviously slighter than that of model group(P 0.05),and the levels of HGF in treatment group was significantly higher than that in model group(P 0.05).Conclusion The atorvastatin can relieve renal interstitial fibrosis caused by UUO in rats by increasing HGF protein expression.