The Effects Of Zhitaiqing Granule On Ultrastructure Of The Aortic Arch In Rabbit With Experimental Atherosclerosis

Objective:To investigate the effects of Zhitaiqing granule on ultrastructure of the aortic arch in rabbit with experimental atherosclerosis. Methods:Choose 10 New Zealand rabbits as blank control randomly and feed them with normal forage,while the rest rabbits are fed with high-fat forage in formula A. After six weeks,hyperlipidemia models are formed and randomly divided into model group,Zhitaiqing treatment group,simvastatin control group and hawthorn tablet control group. From the 7th week,rabbits in treatment and control groups are fed with corresponding drugs while the blank and model groups with the same quantity of normal saline by lavage. After 11 weeks,total cholesterol (CHO),triglyceride (TG),high -density lipoprotein cholesterol (HDL-C),apolipoprotein AI (apo AI),apolipoprotein B (apo B).With the help of scanning electron microscopy,observe the ultrastructure of the aortic arch intimal pathological changes in the organization. Results:in Zhitaiqing group,CHO,LDL-C,and ApoB reduced dramatically (P0.05,P0.01),at the same time,HDL-Cr ose (P0.05),which prohibit vascular endothelial cell ultrastructure injuries. Conclusion:Zhitaiqing Granule takes effects in adjusting the lipid metabolism and anti-atherosclerosis.