Experimental Study on the Anti-atherosclerotic Mechanisms of BuXinTongMai Granules

Objective To study the anti-atherosclerotic effects of BuXinTongMai Granule in a rabbit model of atherosclerosis. Methods Atherosclerotic model was established by feeding high fat diet to rabbits. Forty-eight male rabbits were randomly and evenly divided into six groups: control group,model group (high fat diet),low-dose BuXinTongMai Granule-treated group,mid-dose-treated group,high-dose-treated group and simvastatin group. The levels of blood lipid,plasma endothelin (ET),nitric oxide (NO) and cGMP were measured,and the pathological scores of atherosclerosis were obtained. Results BuXinTongMai Granules significantly decreased the level of TC and TG (P0.05),upregulated the level of plasma NO and cGMP (P0.05),and cut down the pathological score of coronary atherosclerosis. Conclusion BuXinTongMai Granule has anti-atherosclerotic effects on atherogenesis in rabbits with hyperlipoidemia through regulating the blood lipid metabolism,increasing the levels of plasma NO and cGMP and decreasing the level of plasma ET.