Clinical Study of Dexmedetomidine Combined with Propofol for Post-Operative Patients in Intensive Care Unit

Objective: To evaluate the sedative effect and safety of dexmedetomidine combined with propofol for post-operative patients undergoing mechanical ventilation(MV) in intensive care unit(ICU).Methods: A total of 180 cases of post-operative patients undergoing MV with tracheal intubation in ICU were divided randomly and equally into three groups as dexmedetomidine plus propofol group(group A),dexmedetomidine group(group D),and propofol group(group P).In all groups fentanyl was given intravenously continually for analgesia,dose of fentanyl was kept on 0.30 μg/(kg·h).The dose of sedation was regulated according to Ramsay sedative scores maintaining in 3-4 sedative score.During the course,anesthesia up effect time,sedation dose,awakening time,heart rate(HR),mean artery pressure(MAP),respiratory rate(RR),pulse oxygen saturation(SPO 2),adverse reactions were observed and recorded continuously.Results: All groups could reach the goal of sedation needed for ICU patients.Changes of the circulatory system and the dosage of propofol in group A were less than in group P,and there were less adverse reactions in group A than in group P(P 0.05).The dosage of dexmedetomidine in group A was less than in group D.There was no significant difference in HR,MAP,RR,and SPO 2 between groups A and D(P 005).There was significant difference in extubation time between groups P and A or D(P 0.05).Conclusion: Dexmedetomidine combind with propofol can reach the goal of sedation needed for ICU patients,it helps to shorten the dosage of dexmedetomidine and propofol,maintains the respiratory and circulation parameters,and reduces adverse reactions.