Application of remifentanil combined with propofol intravenous anesthesia for colonoscopy

Objective: To study and compare the anesthetic effect and safety of remlfentanll combined with propofol intravenous anesthesia for out-patient clinic colonoscopy. Methods: 160 patients underwent out-patient clinic colonoscopy were randomly allocated into two groups, 80 cases observed group were injected 0.1mg of 2% fentanyl intravenously,followed by propofol of 1.5～2 mg·kg-1 intravenous injection, maintained by 130-180μg· kg-1·min-1 propofol.Control group B (n=80) were only injected propofol intravenously.Colonoscopy was undergone when patient was in the fourth grade anesthesia state.Heart rate (HR)and Sp02 were continuously monitored. Compare with patients reaction and physical sign,the time for complete colonoscopy,average recovery time and success rate were recorded. Results: :Compared with control group, there were less side effect in observed group, and the acceptance rate is higher than that of control group (98.75%). There were significant differences of the DBP, SBP and HR in control group (P 0.05), and the average recovery time was 15 min. Conclusion: The anesthetic side effect and safety of fentanll combined with propofol intravenous anesthesia for colonoscopy is less than propofol intravenous anesthesia only. It had comparable effectiveness and feasibility.