Research on the correlation between insulin resistance and C-reactive protein level of gestational diabetes mellitus

Objective To investigate the risk factors and pathogenesis of gestational diabetes mellitus (GDM), via comparing the differences of placental hormones, high sensitivity C-reactive protein (hs-CRP), insulin resistant, as well as β-cell function in GDM and nondiabetic pregnant women. Methods Fifty patients with GDM and 50 nondiabetic pregnant women as controls group were enrolled into this study. Serum placental hormones, hs-CRP, glucose and insulin were detected. Results Serum hs-CRP level in GDM was significantly higher than that in the control group. No significant difference was found in serum placental hormone. Insulinogenic index of β-cell (△I30/△G30) in GDM patients was significantly lower than that of the controls. hs-CRP was positively related with pre-pregnant weight, pre-pregnant body-mass-index (BMI), fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.287,0.289,0.248,0.299, P0.01), but was inversely related with △I30/△G30(r=-0.509,P0.001). After weight and BMI controled, no relationship was found between hs-CRP either with fasting insulin or HOMA-IR (P0.05). Conclusions Inflammation is associated with insulin resistance during pregnancy. β-cell defect in secretion is found in women with GDM.