ABCA1 Gene R219K and I883M Polymorphism in the Zhuang National Minority in Guangxi

Objective To investigate the distribution of ABCA1 gene R219K and I883M polymorphism in the Zhuang nationality in Guangxi.Methods ABCA1 R219K and I883M genotyping were performed in100 unrelated,healthy,individuals of Zhuang nationality and 121 unrelated healthy individuals of Han population by PCR-RFLP.Results The allele frequencies of ABCA1 gene R219K in the Zhuang nationality were as follows:R=0.640,K=0.360.The allele frequencies of ABCA1 gene I883M in the Zhuang nationality were as follows:I=0.305,M=0.695.Though the frequencies of I allele and II genotype in Zhuang nationality were higher than those in Han population,no significant differences were found in the distribution of ABCA1 gene R219K and I883M genotype and alleles between Zhuang nationality and Han population in Guangxi(P0.05).However,significant differences were found between Zhuang nationality and German population(P0.01).Conclusion The polymorphism of ABCA1 gene R219K and I883M in Zhuang nationality are not different from that in Han population,but are very different from that in Hesperian population.These results indicate that the polymorphism of ABCA1 gene R219K and I883M may have racial differences.The results are useful in the research of population genetics and the association of the SNP with lipid metabolism and the susceptibility to coronary atherosclerosis.