Value of colposcopy in the diagnosis of early pathological changes of cervical intraepithelial neoplasia

Objective To compare the results of colposcopy and histological diagnosis with those of pathological diagnosis after operation on patients with cervical intraepithelial neoplasia (CIN) and to evaluate the related influencing factors of colposcopy in the diagnosis of CIN. Methods The data of 195 patients with CIN confirmed pathologically were retrospectively analyzed. In these 195 cases, 44 patients received physiotherapy(electrocoagulation and laser) and 26(13.3%) and 25(12.8%) patients underwent cervical conization and hysterectomy, respectively. Pathological examination of the cervices was performed on 13 patients during operation. Results The accurate rates of colposcopy and histological examination with colposcopic biopsy were 94.4% and 98.5%, respectively. However, the accurate rate of biopsy was 53.8%(7/13). There was no significant difference in the time for colposcopy, and the quantity of cervical biopsies between misdiagnosed CIN patients and finally diagnosed CIN patients ( P 0.05). There were more menopausal cases in misdiagnosed patients. Conclusion The accurate rate of colposcopy is not significantly correlated with the time for colposcopy, the quantity of cervical biopsies and the preoperative grading of CIN. Histological diagnosis with colposcopic biopsy can not be used for the replacement of cervical conization. Misdiagnosis of patients with CIN can not be avoided by biopsy during operation.