Changes of bone biochemic markers in male patients with type 2 diabetes with osteoporosis

Objective To investigate the change in bone biochemic markers and its mechanism in male patients with type 2 diabetes mellitus(DM).Methods BMD of lumbar spine and proximal femur , in 59 male patients with type 2 diabetes were measured . According to BMD, DM were divided into with (DM-A 2)and without osteoporosis (DM-A 1)groups, several bone biochemic markers and serum testosterone.Results (1) BMD of lumbar spine and Ward's triangle in diabetic patients were significantly lower than that of the controls, which of lateral lumbar spine was the lowest(P0.001).(2)In male patients with type 2 diabetes serum osteocalin was significantly lower than that of the controls (P0.05). Urine calcium to creatinin (Ca/Cr ) was higher than that of the controls, but without statistical significance.(3) There were significant differences of body mass index (BMI), serum testosterone (T),and urine Ca/Cr between DM-A 1 group and DM-A 2 group(P0.05).Conclusion Because of low bone formation and bone turnover rate, BMD in type 2 diabetes mellitus patients decrease. Measurements of BMD at lateral lumber spine may contribute to diagnosing osteoporosis as soon as passible. The male patients with low BMI and T are prone to ostoporosis.