Changes of BMD in male patients with type II diabetes and its affecting factors

Objective To study the changes of bone mineral density (BMD) and its affecting factors in male patients with type Ⅱ diabetes mellitus(DM 2). Methods BMD of lumbar spine and proximal femur, some bone metabolism related biochemical parameters and serum testos terone (T) in 59 male patients with type Ⅱ diabetes were measured and compared with those in 36 healthy men. According to BMD, DM 2 were divided into with (DM A 2)and without osteoporosis (DM A 1)group. Parameters for glucose and mineral metabolism were compared between two groups. Results (1)BMD of lumbar spine and Ward's triangle in diabetic patients were significantly lower than that of the controls, among which lateral lumbar spine was the lowest ( P 0.01). (2) In male patients with type Ⅱ diabetes serum osteocalcin was significantly lower than that of the controls ( P 0.05) .Urine calcium to creatinine (Ca/Cr) was higher than that of the controls, but with no statistical significance. (3) There were significant difference of body mass index (BMI), serum testosterone, postprandial blood glucose, glycated hemoglobin and urine Ca/CR between DM A 1 group and DM A 2 group ( P 0.05). Conclusion The decrease of BMD in type Ⅱ diabetes mellitus patients is due to the decrease of bone formation and bone turnover rate. Determination of BMD at lateral lumber spine may contribute to the early diagnosis of osteoporosis. Male patients with low BMI and T and poor control of hyperglycemia are prone to osteoporosis.