Experimental treatment of diabetes with microencapsulated rat islet cells transplantation

Objective To observe the effect of treating diabetic mice with microcapsulated rat islet cell transplantation.Methods Diabetic mice were randomly divided into 3 groups:control group,no-microencapsulated islet cells transplantation group and microencapsulated islet cells transplantation group.Normal saline,pared rat islet cells and microcapsulated islet cells were respectively transplantated into abdominal cavity of three groups of diabetic mice.Results The isolated islet cells had a good reaction for glucose stimulation.Both the microcapsulated islet cell transplantation and non-microcapsulated islet cell transplantation could be decreased the high blood glucose level,and the former one kept longer.Conclusion It is believed that microcapsulated islet cell transplantation exerts good effect on diabetic mice and the microcapsules have good immuno-isolating function.