Comparative study on the screening methods of cervical intraepithelial neoplasm

Objective To investigate the most effective screening method of the precancerous lesion and early cervical cancer. Methods The Pap smear cytology,the liquid based cytology and the human papillomavirus(HPV) DNA of 280 cases were tested.The results were evaluated by the colposcopic biopsy which was considered as gold standard and were compared with the index of sensitivity,specificity,accuracy,positive predictive value and negative predictive value. Results The sensitivity of three methods was 72.9%,91.5%,85.9%;The specificity was 82.3%,84.1%,69.1%;The accuracy was 80.9%,87.6%,76.8%;The positive predictive value was 76.1%,84.3%,70.1%;The negative predictive value was 79.7%,91.4%,85.4%;The positive likelihood ratio was 4.12,5.75,2.78,and the negative likelihood ratio was 0.33,0.10,0.20 respectively. Conclusions The combined use of liquid based cytology and HPV DNA test is an effective screening method of cervical lesions.If there is cytological or clinical suspected abnormality,the colposcope examination is recommend to make further diagnosis,and this can be contributed to improve the detection rate of cervical lesions.