Efficacy of Imipenem/Cilastatin in Severe Hospital-Acquired Pneumonia

Objective To investigate the clinical effect and safety of Imipenem/Cilastatin on severe hospital-acquired pneumonia(HAP).Methods A total of 93 patients with severe HAP were treated with Imipenem/Cilastatin[0.5-1.0 g,intravenously guttae,q8h or q12h×(7-10 d)].The clinical efficacy and adverse reactions were recorded.The bacteria from sputum were cultured;the antibiotic sensitivity tests were performed.Results The clinical effective rate of Imipenem/Cilastatin for HAP was 78.4%(73/93),the bacterial elimination rate was 89.1%(74/83),and the adverse reaction rate was 5.3%(5/93).Conclusion Imipenem/Cilastatin is effective and safe on severe HAP.According to the changes of bacterial resistance to antibiotics,etiology and clinical effects,the therapeutic scheme should be optimized.