Aggravated anemia and thrombocytopenia caused by piperacillin sodium and tazobactam sodium in three patients with severe liver disease

Three patients with severe liver diseases and infections(all males,aged 40,68,and 50, respectively) were treated with carbapenem,linezolid,and fluconazole.No obvious change of hemogram result was found during the period of drugs use.The therapy was replaced with an Ⅳ infusion of piperacillin sodium and tazobactam sodium 4.5 g every 8 hours due to poor efficacy.Patient 1 developed platelet count decrease and anemia after the treatment with piperacillin sodium and tazobactam sodium for 11 days.Patients 2 and 3 developed platelet count decrease and exacerbation of anemia after the treatment with piperacillin sodium and tazobactam sodium for 4 and 7 days,respectively.Three patients' hemoglobin levels and platelet counts apparently recovered on days 31,21,and 7 after the discontinuation of medication,respectively.