The level of serum tumor supplies group of factors in patients with breast carcinoma

Objective To detect the clinical significance of serum tumor supplies group of factors(TSGF) in patients with breast carcinoma. Methods The serum TSGF level was measured by spectrophotometry in 66 healthy controls and 200 patients with breast carcinoma. Results The TSGF levels ( ±s ) were( 67.5 ± 4.9 )U/ml for initiated tumors, ( 67.5 ± 4.7 )U/ml for nonresponders and ( 65.5 ± 9.6 )U/ml for relapsed or metastases,and were profoundly higher than that in responders [( 55.9 ± 5.1 )U/ml] and controls [( 55.5 ± 5.3 )U/ml] ( P 0.01 ), respectively. TSGF level is not obvious difference between locaregion recurrence and metastases [( 65.0 ± 9.8 )U/ml vs. ( 66.2 ± 9.1 )U/ml] ( P 0.05 ). At the threshold of 64U/ml, TSGF assay indicated breast carcinoma with a specificity of 98.5% and a sensitivity of 60.3% . Conclusion The determination of TSGF might be a useful parameter for assessing of response to treatment and predicting prognosis of breast carcinoma.