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2003•Journal of Hubei InstituteRequires access

Expression of Urokinase-type Plasminogen Activator mRNA in Gastric Cancer Tissues

Jing Zhang

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Abstract

Objective To investigate the expression of urokinase-type plasminogen activator mRNA in gastric cancer tissues and the role in tumor cell invasion and metastasis. Methods uPA mRNA expression was measured in gastric cancer and cancer-adjacent tissue of 45 patients by RT-PCR and, combined with patients' clinical biological feature, was analyzed. Results 38 cases were positive in 45 gastric cancer tissue while 12 cases were positive in all cancer-adjacent tissue. 27 cases of lymphatic metastasis were positive compared with 11 cases of non-lymphatic metastasis. Conclusion Expression of uPA mRNA increases in gastric cancer and it may contribute significantly to gastric invasion and metastasis.

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What this paper is about

Objective To investigate the expression of urokinase-type plasminogen activator mRNA in gastric cancer tissues and the role in tumor cell invasion and metastasis. Methods uPA mRNA expression was measured in gastric cancer and cancer-adjacent tissue of 45 patients by RT-PCR and, combined with patients' clinical biological feature, was analyzed. Results 38 cases were positive in 45 gastric cancer tissue while 12 cases were positive in all cancer-adjacent tissue. 27 cases of lymphatic metastasis were positive compared with 11 cases of non-lymphatic metastasis. Conclusion Expression of uPA mRNA increases in gastric cancer and it may contribute significantly to gastric invasion and metastasis.

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Available abstract

Objective To investigate the expression of urokinase-type plasminogen activator mRNA in gastric cancer tissues and the role in tumor cell invasion and metastasis. Methods uPA mRNA expression was measured in gastric cancer and cancer-adjacent tissue of 45 patients by RT-PCR and, combined with patients' clinical biological feature, was analyzed. Results 38 cases were positive in 45 gastric cancer tissue while 12 cases were positive in all cancer-adjacent tissue. 27 cases of lymphatic metastasis were positive compared with 11 cases of non-lymphatic metastasis. Conclusion Expression of uPA mRNA increases in gastric cancer and it may contribute significantly to gastric invasion and metastasis.

Key concepts: Plasminogen activator, Urokinase, Metastasis, Cancer, Lymphatic system, Urokinase receptor, Messenger RNA, Pathology

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