Synthesis of p-methoxyacetophenone using AlPW_(12)O_(40) as catalyst

AlPW12O40 was synthesized using H3PW12O40 and AlCl3·6H2O as raw materials,then used as a catalyst to study the acylation reaction of anisole(AN) and acetic anhydride(AA),the main product of reaction is p-methoxyacetophenone.The effects of anisole and acetic anhydride molar ratio,catalyst addition amount,reaction temperature and reaction time on acylation reaction were examined through orthogonal experiments.The suitable reaction conditions were anisole and acetic anhydride mole ratio 1∶1.5,catalyst amount 1 g,reaction temperature 100 ℃,reaction time 4 h.The yield of product is as high as 69.80%.Under optimal conditions,the effects of different substrates and acylating agents on the reaction and catalytic effect of different metal phosphotungstate were investigated.The effects of different heating methods on the catalytic reaction were comparised.The results showed that AlPW12O40 is the best catalyst and microwave heat is better.