Immunomodulatory effects of Panax ginseng oligopeptide of Jilin Province

This paper investigates the immunomodulatory effects of Panax ginseng oligopeptide of Jilin providence. A total of 280 specific pathogen free(SPF) female BALB/c mice are randomly divided into 7 groups: the control group, the whey protein group(whey protein of 150 mg/kg) and five groups of Panax ginseng oligopeptide(GOP) at the doses of 37.5, 75, 150, 300 and 600 mg/kg. After30 days, seven assays are performed to determine the cell-mediated immunity, the humoral immunity, the macrophage phagocytosis and the natural killer(NK) cell activity in the mice, including the splenic lymphocyte proliferation and the delayed- type hypersensitivity assays(for cell-mediated immunity), the Ig M antibody response of spleen to SRBC and serum hemolysin level assays(for humoral immunity), the carbon clearance assay and the phagocytic capacity of peritoneal cavity phagocytes assays(for macrophage phagocytosis) and the NK cell activity assays. The results show that the GOP helps significantly to increase the proliferation response of the splenic lymphocyte to the Con A, the delayed-type hypersensitivity to the SRBC, the Ig M antibody response of the spleen to the SRBC, the serum hemolysin level, the 37.5 mg/kg macrophage phagocytosis carbon clearance assay, the phagocytic rate(mg/kg) and the phagocytic index, and the NK cell activity(37.5 mg/kg), and the effects are better than those of the whey protein. In conclusion,the GOP could improve the immune functions in mice, by enhancing the functions of the cell- mediated immunity, the humoral immunity, the macrophage phagocytosis and the NK cell activity.