Angiotensin converting enzyme and aldosterone synthase gene polymorphism in patients with hypertensive disorder complicating pregnancy

【Objective】 To Investigate the relationship between polymorphism of an insertion /deletion (I/D) for angiotensin converting enzyme (ACE) genes and aldosterone synthase (CYP11B2) gene -344T/C mutation and hypertensive disorder in pregnancy. 【Methods】 A total of 87 patients with hypertensive disorder complicating pregnancy and 175 normal controls were surveyed. The genotype for I/D of ACE and -344T/C mutation of CYP11B2 were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), respectively. 【Results】 The odds ratios (OR) calculated for those exposed to I/D genotype, DD genotype and D allele were 1.981, 2.347 and 1.737 respectively in ACE gene; OR calculated for those exposed to TC-genotype, CC-genotype and C allele were 1.577, 6.081 and 2.114 in CYP11B2 gene. In the same cases, the OR of combinational DD-TC gene was 6.019. The samples of II-CC、ID-CC gene and DD-CC gene were not enough. There was no statistical difference in other combination genes (P 0.05).【Conclusion】 Site mutation allele gene of insertion (I)/ deletion (D) polymorphism for angiotensin converting enzyme (ACE) gene and -344T/C aldosterone synthase (CYP11B2) gene might increase the susceptibility of hypertensive disorder complicating pregnancy. It has a positive co-influence on the hypertensive disorder complicating pregnancy.