Preparation and Quality Control of Naproxen Microcapsule Suppository

OBJECTIVE: To prepare Naproxen microcapsule suppository and to investigate quality control of it.METHODS: Naproxen microcapsule suppository was prepared with naproxen microcapsule and mixed fatty glyceride by means of hot melting process.The quality of microcapsule suppository was evaluated according to the requirements of Chinese Pharmacopeia (2010 edition) in respect of appearance,weight variation,content determination and release rate.In vitro drug release rate of Naproxen microcapsule suppository was compared with that of Naproxen microcapsule and conventional suppository.RESULTS: The appearance,weight variation and content determination of Naproxen microcapsule suppository were in line with the requirements of Chinese Pharmacopeia.Drug release rate of Naproxen microcapsule suppository was 90.87% at 48 h in vitro,that of microcapsule was 91.02% at 36 h,and that of conventional suppository was 94.51% at 3 h.CONCLUSION: The preparation process of Naproxen microcapsule suppository is simple.And it has good quality control and sustained release.