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2010•Zhongguo shiyan fangjixue zazhiRequires access

Preparation and Vitro Release Characteristics of Baicalin Water-solubility Suppository

Bin Xiao

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Abstract

Objective:To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method:To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result:Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster,achieve maximum releasing within 40 minutes and it's releasing consistent with Weibull Distribution Model. Conclusion:This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6.

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What this paper is about

Objective:To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method:To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result:Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster,achieve maximum releasing within 40 minutes and it's releasing consistent with Weibull Distribution Model. Conclusion:This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6.

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Available abstract

Objective:To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method:To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result:Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster,achieve maximum releasing within 40 minutes and it's releasing consistent with Weibull Distribution Model. Conclusion:This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6.

Key concepts: Suppository, Baicalin, Chromatography, PEG ratio, Solubility, Chemistry, Dissolution, Polyethylene glycol

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