2007•Unpublished venueRequires access

Cell Apoptosis and the Expression of FAS/FASL mRNA in Rats with Pulmonary Fibrosis

Bing Wan

Abstract

Objective To investigate the significance of cell apoptosis and FAS/FAS-L mRNA in the lung tissue of rats with pulmonary fibrosis.Methods The pulmonary fibrosis model in rat was established by bleomycin.TUNEL and RT-PCR were used to observe the cell apoptosis of rat's lung tissue and mRNA expression.Results The model was reproduced successfully.Compared with the control group,in model group the cell apoptosis was kept up-regulating from the 1st day to the 28th day and the peak appeared around the 14th day.The situation of the expression of FAS/FAS-L mRNA was the same as that of cell apoptosis.Conclusion The up regulation of cell apoptosis and the expression of FAS/FAS-L mRNA may play an important role in the development of pulmonary fibrosis.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Apoptosis, Bleomycin, Fas ligand, Pulmonary fibrosis, TUNEL assay, Messenger RNA, Cell, Fas receptor