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2007•Journal of Jiangsu UniversityRequires access

Cell apoptosis and gene expression of Fas/FasL in rats with pulmonary fibrosis

Yu-Lan Yan

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Abstract

Objective: To investigate the expression and significance of cell apoptosis and Fas/Fas-L gene in the lung tissue of rats with pulmonary fibrosis.Methods: The pulmonary fibrosis model in rat was established by bleomycin.TUNEL、 RT-PCR and Western Blot were used to observe cell apoptosis and Fas/Fas-L gene expression. Results: The model was reproduced successfully.Compared with the control group,cell apoptosis and Fas/Fas-L gene expression were significantly up-regulated in the rat′s lung tissue in model group. Conclusion: The up regulation of expression of cell apoptosis and Fas/Fas-L gene may play an important role in the pathogenesis and development of pulmonary fibrosis.

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What this paper is about

Objective: To investigate the expression and significance of cell apoptosis and Fas/Fas-L gene in the lung tissue of rats with pulmonary fibrosis.Methods: The pulmonary fibrosis model in rat was established by bleomycin.TUNEL、 RT-PCR and Western Blot were used to observe cell apoptosis and Fas/Fas-L gene expression. Results: The model was reproduced successfully.Compared with the control group,cell apoptosis and Fas/Fas-L gene expression were significantly up-regulated in the rat′s lung tissue in model group. Conclusion: The up regulation of expression of cell apoptosis and Fas/Fas-L gene may play an important role in the pathogenesis and development of pulmonary fibrosis.

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Available abstract

Objective: To investigate the expression and significance of cell apoptosis and Fas/Fas-L gene in the lung tissue of rats with pulmonary fibrosis.Methods: The pulmonary fibrosis model in rat was established by bleomycin.TUNEL、 RT-PCR and Western Blot were used to observe cell apoptosis and Fas/Fas-L gene expression. Results: The model was reproduced successfully.Compared with the control group,cell apoptosis and Fas/Fas-L gene expression were significantly up-regulated in the rat′s lung tissue in model group. Conclusion: The up regulation of expression of cell apoptosis and Fas/Fas-L gene may play an important role in the pathogenesis and development of pulmonary fibrosis.

Key concepts: Fas ligand, Apoptosis, Bleomycin, Pulmonary fibrosis, TUNEL assay, Fas receptor, Cell, Gene expression

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